100 A.D.). Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein. This is just one more way of ensuring your safety and that of our staff. Institute of Chinese Medicine and State Key … The mechanism of SF-induced CYP3A expression is unknown. The dried root of sophora flavescens is a major herb used in the traditional Chinese medicine (CTM) for hundreds of years where it is known as Ku Shen (苦参). Reseeds, perennial. Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice. Results are shown as the fold induction of luciferase activity over the vehicle control. Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats, PXR: a center of transcriptional regulation in cancer, Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR, The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes, The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor, Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway, Screening of active ingredients of herbal medicine for interaction with CYP450 3A4. Sophora has anti-inflammatory and antioxidant properties.1 Sophora flavescens may have the potential for treatment of chronic inflammatory disorders such as rheumatoid arthritis.2 Sophora could possibly be used as a treatment for mast cell-derived allergic inflammatory diseases.3 Sophora may be an effective cholesterol-lowering agent and useful for preventing hypercholesterolemic atherosclerosis.4 Sources: 1. Some features of the site may not work correctly. Concomitant oral administration of Sophora extract (0.158 g/kg or 0.63 g/kg, p.o.) Ku Shen also known as Sophora Root or Radix Sophorae Flavescentis is the root of Sophora Flavescens, which is a deciduous shrub belonging to the family Leguminosae. Ku shen is a Chinese herbal remedy made from the root of S. falvescens. Charles Darwin, originator of the biological theory of evolution, regards the book as the “ancient Chinese encyclopedia”. Matrine and oxymatrine are two of the major phytochemical … Cytotoxic effects of flavonoids from root of Sophora flavescens in cancer cells. Although the chemical constituents have been clarified by our previous studies, the metabolic transformation of “Dogel ebs” in vivo was still unclear. Pills made with dried root of sophora flavescens and honey is taken with mint soup to treat high-grade fevers. It has a medicinal history of more than 2,000 years. The roots of Sophora flavescens (SF) are clinically used as a traditional Chinese medicine for the treatment of various lung diseases. The pregnane X receptor: from bench to bedside. Select Your Cookie Preferences. Sophora flavescens (syn. Sophora (see Figure 2) was first described in the Shennong Bencao Jing (ca. Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. We use cookies to ensure that we give you the best experience on our website. Disclaimer: The Ben Cao Medical Book is translated by ChinaAbout.net. In the current study, we tested the hypothesis that SF-induced CYP3A expression is mediated by the activation of pregnane X receptor (PXR). This genus contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceania, and the Pacific islands. Entering meridians include the Urinary Bladder, Heart, Liver, Large Intestine, Stomach and Small Intestine. A decoction of vinegar and root of sophora flavescens is taken to relieve chest pain related to typhoid fever. English; Chinese; CONTACT US: +44 (0) 1245 350822. It was recently reported that SF up-regulates CYP3A expression. Effects of matrine and oxymatrine on catalytic activity of cytochrome p450s in rats. In traditional Chinese medicine (TCM), Sophora flavescens has been used extensively, mainly in combination with other medicinal plants in prescriptions to treat fever, dysentery, hematochezia, jaundice, oliguria, vulvar swelling, asthma, eczema, inflammatory disorders, ulcers and diseases associated with skin burns. On the basis of his predecessors’ achievements in the pharmacological studies, Li contributed further by supplementing and rectifying many past mistakes and misconception in relate to nature of many medicinal substances and causes of various illnesses. Pioneering the development of Chinese medicine. Ethnopharmacological relevance. Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. Identification of PXR activator(s) in SF aqueous extract. PXR- and CAR-mediated herbal effect on human diseases. Regulation of cyp3a gene transcription by the pregnane x receptor. Sophora flavescens is a species of plant in the genus ''Sophora''. ← Dictamnus Albus Root As Medicine – Ben Cao Medical Book, Cimicifuga Rhizoma As Medicine – Ben Cao Medical Book →, 5 Health Benefits of Soju - Ben Cao Medical Book, Health Benefits of Rubus Chingii - Ben Cao Medical Book, 4 Amazing Health Benefits of Pistachios - Ben Cao Medical Book, 4 Health Benefits of Cuscuta Chinensis - Ben Cao Medical Book, Health Benefits of Dioscorea Bulbifera - Ben Cao Medical Book, 5 Amazing Uses And Health Benefits of Lotus Leaves - Ben Cao Medical Book, Barn Swallows’ Mud Nest As Medicine – Ben Cao Medical Book, Bees’ Nest As Medicine – Ben Cao Medical Book, Dung Balls As Medicine – Ben Cao Medical Book. Sophora flavescens | Memorial Sloan Kettering Cancer Center We're committed to providing you with the very best cancer care, and your safety continues to be a top priority. Change the quantity to reflect how many ounces youd like. Pregnane X receptor activation potentiates ritonavir hepatotoxicity. AIM AND OBJECTIVE:Five-Flavor Sophora flavescens Enteric-Coated Capsules (FSEC) are the only proprietary Chinese medicine approved for the treatment of ulcerative colitis (UC) in China. Dehua Liu. Dong H.L., Dong S.S., Dai Y.C., Beom J.K., Yun Y.L., Young H.K. Your email address will not be published. It was recently reported that SF up-regulates CYP3A expression. Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens. Sophora flavescens is the primary component of Equilibrant, an oxymatrine-based … 1 oz: $20.00 Want more than 1 ounce? The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. China Sophora Flavescens Root Extract manufacturers - Select 2020 high quality Sophora Flavescens Root Extract products in best price from certified Chinese Natural Plant Extract manufacturers, Herbal Extract Powder suppliers, wholesalers and factory on Made-in-China.com Required fields are marked *. We use cookies and similar tools to enhance your shopping experience, to provide our services, understand how customers use … The data are presented as means (n 3 at each concentration). A new compound, kushenol Z (KZ), and 14 known flavonoids were isolated from SF. Compiled and written by Li Shi-zhen (1518~1593), a medical expert of the Ming Dynasty (1368-1644) over 27 years. Sophora flavescens root is known as Ku Shen in traditional Chinese medicine. The book reflects the pharmaceutical achievements and developments of East Asia before the 16th century. - "The Chinese Herbal Medicine Sophora flavescens Activates Pregnane X Receptor" FIG. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. In this study, we investigated the mechanism by which SF inhibits proliferation and induces apoptosis in non-small-cell lung cancer (NSCLC) cells. Avoid taking veratrum nigrum root and root of sophora flavescens at the same time; Patients with deficiency and cold in spleen or stomach should not take medicine that contains root of sophora flavescens. The root of Sophora flavescens has a long history in the traditional medicine of many countries, including China, Japan, Korea, India and some countries in Europe. In the current study, we tested the hypothesis that SF-induced CYP3A expression is … Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor. "Anti-inflammatory and anti-oxidant effec… Although the quinolizidine alkaloids and flavonoids, the main active components of the traditional Chinese medicine Sophora flavescens, have been largely investigated, a new matrine alkaloid derivative 9alpha-hydroxy-7,11-dehydromatrine (1) and a rare 1,4-diazaindan-type alkaloid flavascensine (17), together with 15 known alkaloids, were isolated from S. flavescens. Sophora flavescens protects against mycobacterial Trehalose Dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages. About fifteen of these species have a long history of use in traditional Chinese medicines. It is commonly used for the treatment of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). Oceanica, and 14 known flavonoids were isolated from SF aqueous extract of a Chinese herbal Sophora. 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